BioMed Labs

Delivery Sequence

Four stages.
One precision platform.

From patch application to systemic uptake — the complete delivery sequence of the BioMed Labs microcrystal transdermal platform.

1
2
3
4
01

Apply

Patch placement on clean, dry skin

The patch is removed from its foil sachet and applied to a clean, dry area of skin — typically the upper arm or shoulder. Light pressure for 10–15 seconds ensures full contact between the microneedle array and the skin surface. No preparation, no clinical setting required.

  • Peel-and-press application
  • Upper arm, shoulder, or abdomen
  • 10–15 seconds firm contact
  • Wear time: 8–12 hours
02

Microstructure Contact

Microneedle tips engage the skin surface

The dissolvable microneedle tips — each less than 200 µm in height — make contact with the outermost skin layer. They do not penetrate the dermis or reach nerve endings. Skin moisture begins to soften the polymer tips, initiating the dissolution sequence.

  • Tip height < 200 µm
  • No dermal penetration
  • Polymer softening begins on contact
  • Pain-free by design
03

Dissolution

Microcrystals dissolve and release active compound

As the polymer matrix dissolves, the microcrystal payload is exposed at the skin interface. Crystal dissolution releases the active compound in a controlled manner governed by particle size distribution and crystal habit — not by a rate-limiting membrane. The release profile is predictable and reproducible.

  • Polymer matrix dissolves in skin moisture
  • Microcrystals exposed at interface
  • Release rate set by crystal geometry
  • No dose-dumping mechanism
04

Delivery Platform

Compound transits to the systemic circulation

The dissolved active compound permeates through the viable epidermis and into the upper dermis, where the capillary network provides access to systemic circulation. The GI tract, hepatic first-pass metabolism, and gastric acid are bypassed entirely. Uptake is governed by dermal perfusion and compound permeability.

  • Transdermal permeation through epidermis
  • Capillary uptake in upper dermis
  • GI tract bypassed entirely
  • First-pass metabolism avoided

Common questions

Platform FAQ

Does the patch hurt?
No. The microneedle tips are less than 200 µm tall and dissolve on contact with skin moisture. They do not reach nerve endings in the dermis.
How long should the patch be worn?
The recommended wear time is 8–12 hours. The patch can be worn during normal daily activity including light exercise.
Can the patch be worn in water?
The patch is not designed for immersion. Brief contact with water (e.g. hand washing) is generally tolerated, but prolonged water exposure may affect adhesion.
What happens to the microneedle tips after application?
The tips dissolve completely in skin moisture. There is no residual needle material remaining in the skin after removal.
Is the platform suitable for other active compounds?
Yes. The microcrystal platform is compound-agnostic. Formulation parameters are adjusted per active to accommodate solubility, molecular weight, and target release window.

Ready to explore the platform?

Explore the underlying technology or enquire about B2B supply and distribution.

Platform TechnologyB2B Enquiries